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Basic and Clinical Neuroscience، جلد ۲، شماره ۳، صفحات ۵۱-۵۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
The Effect of the Flavonoid Quercetin on Pain Sensation in Diabetic Rats |
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| چکیده انگلیسی مقاله |
Introduction: Hyperalgesia is considered as one of the marked signs of subchronic diabetes mellitus in patients that could affect their lifestyle. This study was designed to investigate the anti-nociceptive effect of chronic administration of quercetin in streptozotocin (STZ)-diabetic rats using formalin and hot tail immersion tests. Methods: Rats were divided into control, control or diabetic groups receiving sodium salicylate, untreated diabetic, and quercetin-treated control and diabetic groups. The treatment groups received i.p. administration of quercetin at a dose of 10 mg/kg for 6 weeks. Finally, hyperalgesia were assessed using standard formalin and hot tail immersion tests. Meanwhile, some markers of oxidative stress were also measured in brain tissue.Results: Quercetin or SS treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (p< 0.05). Regarding hot tail immersion test, diabetic rats showed a significant reduction in tail flick latency as compared to control ones (p< 0.05) and quercetin treatment of diabetic rats did significantly increase this latency relative to untreated diabetics (p< 0.05). Quercetin treatment of diabetic rats also significantly decreased brain level of malondialdehyde (MDA) (p< 0.05) and nitrite (p< 0.05) and slightly increased activity of superoxide dismutase (SOD) relative to diabetics. Discussion: Taken together, chronic administration of quercetin could attenuate nociceptive score in chronic phase of formalin test in streptozotocin-diabetic rats and could also increase threshold of thermal nociception. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
جمشید نارنجکار | jamshid narenjkar
مهرداد روغنی | mehrdad roghani
هانیه alambeygi | hanieh alambeygi
فرنوش صداقتی | farnoosh sedaghati
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-64&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Neuroscience |
| نوع مقاله منتشر شده |
Original |
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