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Pharmaceutical and Biomedical Research، جلد ۸، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Prophylactic Effect of Chloroquine and Hydroxy chloroquine in COVID-19 Treatment |
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| چکیده انگلیسی مقاله |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named 'coronavirus disease 2019' (COVID-19), which threatens human health and public safety.Hydroxychloroquine (HCQ) is an anti-malaria drug; its antiviral properties are controversial,and some in vitro studies approved its antiviral effects. Many efforts have been made to prevent and treat coronavirus COVID-19 disease, but effective drugs for complete eradication of COVID-19 have not been found yet, and all of them are supportive. We try to review some new aspects of HCQ efficacy in the prevention and treatment of COVID-19 infection. Also, some data from recent clinical trials were studied. It has been shown that HCQ may improve some symptoms of patients, but in severe or critical stages did not have significant therapeutic effects and not reduce the rate of mortality .In the present review article, we explained some results of recent researches, including clinical trials about the effects of HCQ in the prevention and treatment of COVID-19infection.Some studies revealed HCQ beneficial effects in outpatients, and some data showed its hazardous impacts on the heart. The available evidence suggests that CQ or HCQ does not improve clinical outcomes in COVID-19. Well-designed randomized trials are required for assessing the efficacy and safety of HCQ and CQ for COVID- It was suggested that the dose of HCQ administration must be adjusted and monitored correctly; furthermore, the levels of some myocardial biomarkers such as troponin must be measured in mild to moderate, severe, and critical infection. Also combination therapy with other drugs such as azithromycin may have better anti-inflammatory and antiviral effects . Keywords: Hydroxychloroquine, COVID-19, OT-interval, Azithromycin, Replication. |
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| کلیدواژه‌های انگلیسی مقاله |
Hydroxychloroquine, COVID-19, OT-interval, Azithromycin, Replication. . |
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| نویسندگان مقاله |
| Amin Ataie
Department of Toxicology and Pharmacology, Babol University of Medical Science, Babol, Iran
| Ramin Ataee
Pharmaceutical sciences research center, Hemoglobinopathy institute, Mazandaran University of medical sciences, Sari Iran
| Hossein Khaleghzadeh
Department of Physiology, Babol University of Medical Sciences,Babol, Iran
| Razieh Mansouri
Department of Toxicology and Pharmacology, Babol University of Medical Science, Babol, Iran
| Fatemeh Alibabaei
Department of Toxicology and Pharmacology, Babol University of Medical Science, Babol, Iran
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-991-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فارماکولوژی |
| نوع مقاله منتشر شده |
مروری |
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