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Pharmaceutical and Biomedical Research، جلد ۷، شماره ۴، صفحات ۲۲۱-۲۵۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
A Review on Cyperus rotundus: Ancient Weed to Modern Elixir of Life Phytochemistry and Therapeutic Uses of Cyperus rotundus (Mustaka) |
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| چکیده انگلیسی مقاله |
Background: Since time immemorial, humans have identified several herbs to treat various ailments. With the advancement of science and state-of-the-art technologies, different herbal extracts and chemical constituents of herbs were identified as therapeutic targets. Cyperus rotundus, also called mustaka, is one of the most ancient herbs widely distributed in tropical and subtropical regions across the globe. The tuberous and aerial parts of the herb were identified to possess various pharmacological properties. Objectives: This review focuses on the various phytocompounds of mustaka and how these compounds exert pharmacological effects and their mode of action. The molecular and cellular effects of mustaka were also discussed based on the preclinical and clinical reports available using an array of in vitro, in vivo, and ex vivo methodologies. Methods: The information from Google Scholar, Science direct, PUBMED, were reviewed with a special focus on the mode of action of C. rotundus from the data on animal and pre-clinical experiments to treat various diseases. Conclusion: Based on the literature available on C. rotundus in Google Scholar, Science Direct, and PubMed, the pharmacological properties of mustaka were reviewed with a particular focus on its neuropharmacological activities. The mode of action of C. rotundus and its bioactive metabolites at the molecular biology level were demonstrated based on animal and preclinical experiments to cure various ailments. These diverse effects prove C. rotundus as a valuable traditional medicine for treating various disorders. |
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| کلیدواژه‌های انگلیسی مقاله |
Anti-oxidant activity, Anti-Alzheimer, Anti-Parkinson, Cyperus rotundus, Neuropharmacology, Nutgrass, Nutsedge, Total oligomeric flavonoids |
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| نویسندگان مقاله |
| Hemanth Kumar Kandikattu
Department of Medicine, Tulane Eosinophilic Disorders Center, Medicine-Pulmonary Diseases, Tulane University, New Orleans, Louisiana, USA.
| Narayanappa Amruta
Department of Neuroscience, School of Medicine, Tulane University New Orleans, Louisiana, USA.
| Farhath Khanum
Department of Medicine, Tulane Eosinophilic Disorders Center, Medicine-Pulmonary Diseases, Tulane University, New Orleans, Louisiana, USA.
| V.V.P.C. Narayana
Biochemistry and Nanosciences Dscipline, Defence Food Research Laboratory, Mysore, Karnataka, India.
| Doddaga Srinivasulu
Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-541-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فارماکولوژی |
| نوع مقاله منتشر شده |
مروری |
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