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Pharmaceutical and Biomedical Research، جلد ۷، شماره ۴، صفحات ۲۸۵-۲۹۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effects of Isoniazid on the Acquisition and Expression of Morphine Dependence in Male Mice |
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| چکیده انگلیسی مقاله |
Background: GABAergic drugs have extensive interference with morphine's pharmacological effects, including dependence. Objectives: The present study was conducted to evaluate the effects of isoniazid, a GABAergic agent, on the acquisition and expression of morphine-induced dependence in male mice. Methods: Sixty-four male mice were used. The mice became dependent on morphine by administrating ten doses of morphine in four days. For the precipitation of the morphine withdrawal signs (jumping, diarrhea, and weight loss), two hours after the last dose of morphine, the mice received naloxone (4 mg/kg, IP). In the expression experiment, four groups of mice received saline or isoniazid (25, 50, and 75 mg/kg, IP) one hour before naloxone. In the acquisition experiment, the other four groups, one hour before the first six doses of morphine, received saline or isoniazid (25, 50, and 75 mg/kg, IP). Results: In the expression experiment, all doses of isoniazid decreased the number of jumping in mice, but only the lowest dose influenced diarrhea (increased weight of diarrheal stool) significantly. The higher doses of isoniazid (50 and 75 mg/kg, IP) caused a significant reduction in the percentage of weight loss, but its lowest dose (25 mg/kg, IP) significantly increased the sign. In the acquisition experiment, isoniazid (25, 50 mg/kg IP) decreased the number of jumping and the percentage of weight loss, but not the weight of diarrheal stool. Conclusion: Isoniazid may be a good candidate to prevent morphine withdrawal signs. |
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| کلیدواژه‌های انگلیسی مقاله |
Isoniazid, Morphine dependence, Naloxone, Substance withdrawal syndrome, Mice |
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| نویسندگان مقاله |
| Amir Abbas Barzegari
Department of Biology, Faculty of Basic Science, University of Maragheh, Maragheh, East Azerbaijan Province, Iran.
| Kamran Shahabi
Department of Biology, Faculty of Basic Science, University of Maragheh, Maragheh, East Azerbaijan Province, Iran.
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-322-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فارماکولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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